19 of the Russian's 21 titles have been won on hard surfaces
A comeback the Russian player claimed his first trophy for 882 days with success over Corentin Moutet in the competition championship match.
The Russian, a former world number one, has endured a challenging period, winning just one win at the major tournaments and experiencing a meltdown at the American major.
Medvedev's inconsistency on the ATP Tour - and struggles with his serving in particular - caused him dropping out of the elite rankings and ultimately splitting with former trainer Cervara.
Presently training with Thomas Johansson and his other coach, Medvedev has consistently progressed in the past month - culminating in a hard-fought three-set win over Frenchman Corentin Moutet.
This marks Medvedev's initial trophy since the Italian tournament and initial on a hard court since March of the previous year.
Victory also signifies Medvedev has won twenty-one titles at 21 different tournaments.
"It's the first time I am participating in a tournament with my two daughters at once, so to secure a title is really nice," said world number 14 Daniil Medvedev.
"This victory is in dedication of my child my daughter, because the first title I got when my first daughter Alisa was born was for her."
The tennis star, the past champion, had been defeated in his previous six finals, including in Halle in the past months.
Medvedev's retrieving strategy and frequent reactions on court had prompted observers to doubt if his ability to compete at the top level was finished.
But the 29-year-old has altered his approach in recent weeks, striving to advance forward and compete assertively, reinforced by an enhanced serve.
The champion recovered from a break down in the opening set against the challenging opponent, taking four of the last five games to take the lead.
The competitors exchanged service breaks in the second set before the Frenchman, bidding for his first ATP Tour championship, took control to push for a third set.
Moutet defended 4 initial break points in a competitive third set before the Russian won the break to fifteen to serve for the match.
Suitably, he earned the title with a rally at the front of the court, with his opponent unable to handle a volley after two hours and 38 minutes.